This is not taking into account the type of mutations one can reasonably expect to occur in the next generation of ‘more virulent’ variants.
Geert Vanden Bossche has been predicting that the latter will primarily use changes in their glycosylation to overcome population-level immune pressure currently exerted on viral virulence. It’s highly unlikely that the miraculous monoclonals will even be able to reach the critical neutralizing sites within spike protein. The keyword is ‘steric hindrance’. One of the key roles of glycans grafted on viral proteins is to hide/ mask vulnerable domains!
https://www.israel21c.org/breakthrough-antibody-discovery-could-mean-end-to-covid-vaccines/
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